L-cysteine Arrests Apoptosis of Spiral Ganglion Neuron
نویسندگان
چکیده
منابع مشابه
Calpain Inhibitor PD150606 Attenuates Glutamate Induced Spiral Ganglion Neuron Apoptosis through Apoptosis Inducing Factor Pathway In Vitro
OBJECTIVE This research aimed to investigate whether glutamate induced spiral ganglion neurons (SGNs) apoptosis through apoptosis inducing factor (AIF) pathway. And verify whether PD150606, a calpain inhibitor could prevent apoptosis by inhibiting cleaving and releasing AIF in mitochondrion. METHODS SGNs of postnatal days 0-3 were harvested and cultured in dishes. 20 mM Glu, the caspase inhib...
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Type I spiral ganglion neurons have a unique role relative to other sensory afferents because, as a single population, they must convey the richness, complexity, and precision of auditory information as they shape signals transmitted to the brain. To understand better the sophistication of spiral ganglion response properties, we compared somatic whole-cell current-clamp recordings from basal an...
متن کاملComplex regulation of spiral ganglion neuron firing patterns by neurotrophin-3.
Auditory information is conveyed into the CNS via the spiral ganglion neurons, cells that possess distinctive electrophysiological properties that vary according to their cochlear innervation. Neurons from the base of the cochlea fire action potentials with shorter latencies and durations with more rapid accommodation than apical neurons (Adamson et al., 2002b). Interestingly, these features ar...
متن کاملThe afferent signaling complex: Regulation of type I spiral ganglion neuron responses in the auditory periphery
The spiral ganglion neurons (SGNs) are the first action potential generating neurons in the auditory pathway. The type I SGNs contact the sensory inner hair cells via their peripheral dendrites and relay auditory information to the brainstem via their central axon fibers. Individual afferent fibers show differences in response properties that are essential for normal hearing. The mechanisms tha...
متن کاملEarly Development of the Spiral Ganglion
The spiral ganglion develops in parallel with the patterning and morphogenesis of the inner ear (Fig. 2.1). The inner ear arises from the otic placode, an ectodermal thickening that forms adjacent to the 5th and 6th rhombomeres of the hindbrain in vertebrates other than the lamprey (Kuratani et al., 1998). This occurs at the 8–10 somite stage of development, which corresponds to E8.5 in mouse (...
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ژورنال
عنوان ژورنال: Otolaryngology–Head and Neck Surgery
سال: 2010
ISSN: 0194-5998,1097-6817
DOI: 10.1016/j.otohns.2010.06.164